Search Southeast Missouri hotels

Start date: Check-in selected.
End date: Check-out
    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Top hotels and accommodation in Southeast Missouri

Postcard Cabins St. Francois

2.0 star property
10.0 out of 10, Exceptional, (30)
"Sweet cabin"
The price is AU$204
includes taxes & fees
7 Sept - 8 Sept
Postcard Cabins St. Francois

The Farmstead Hotel

2.5 star property
8.8 out of 10, Excellent, (406)
"Great place. "
The price is AU$198
includes taxes & fees
7 Sept - 8 Sept
The Farmstead Hotel

Super 8 by Wyndham Farmington

2.0 star property
8.0 out of 10, Very good, (583)
"Very friendly staff who make sure guests are taken care of! Clean, great location, and safe place to stay. "
The price is AU$93
includes taxes & fees
11 Sept - 12 Sept
Super 8 by Wyndham Farmington

Holiday Inn Express & Suites Perryville by IHG

2.5 star property
9.4 out of 10, Exceptional, (502)
"Have stayed here the past 3 years during the Laid Back on I-55 Truck Show! Great place to stay! The breakfast is fantastic!! The staff does not disappoint!! "
The price is AU$166
includes taxes & fees
7 Sept - 8 Sept
Holiday Inn Express & Suites Perryville by IHG

Drury Inn & Suites Jackson MO

3.0 star property
9.6 out of 10, Exceptional, (1002)
"Employees were extremely helpful and happy to help!"
The price is AU$145
includes taxes & fees
10 Sept - 11 Sept
Drury Inn & Suites Jackson MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 star property
8.0 out of 10, Very good, (1000)
"Great location"
The price is AU$91
includes taxes & fees
14 Sept - 15 Sept
Baymont Inn and Suites by Wyndham Farmington, MO

Pear Tree Inn Cape Girardeau West

2.5 star property
9.0 out of 10, Wonderful, (1002)
"Great place to stay. Safe and quiet indoors and close to get in the road again tomorrow. Staff was friendly! "
The price is AU$121
includes taxes & fees
7 Sept - 8 Sept
Pear Tree Inn Cape Girardeau West

Super 8 by Wyndham Perryville

2.0 star property
8.4 out of 10, Very good, (904)
" Love the stay and staff was great "
The price is AU$126
includes taxes & fees
11 Sept - 12 Sept
Super 8 by Wyndham Perryville

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

2.5 star property
9.4 out of 10, Exceptional, (676)
"Love staying at the holiday inn ans suites "
The price is AU$243
includes taxes & fees
7 Sept - 8 Sept
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (988)
"The staff was beyond friendly, the free breakfast did not disappointed, and we were just genuinely happy with our stay."
The price is AU$155
includes taxes & fees
13 Sept - 14 Sept
Drury Inn & Suites Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3.0 star property
8.8 out of 10, Excellent, (610)
"Excellent place to stay. Breakfast was good and staff was friendly. "
The price is AU$139
includes taxes & fees
7 Sept - 8 Sept
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Drury Inn & Suites Hayti Caruthersville

3.0 star property
9.4 out of 10, Exceptional, (1000)
"Great place"
The price is AU$164
includes taxes & fees
19 Sept - 20 Sept
Drury Inn & Suites Hayti Caruthersville

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1001)
"Excellent place to stay "
The price is AU$121
includes taxes & fees
14 Sept - 15 Sept
Pear Tree Inn Cape Girardeau Near the Medical Center

Comfort Inn Festus - St Louis South

2.5 star property
8.0 out of 10, Very good, (872)
"The room was clean and the hallways were clean. The breakfast was good and the room was affordable. Just what we were looking for!"
The price is AU$138
includes taxes & fees
14 Sept - 15 Sept
Comfort Inn Festus - St Louis South

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1002)
"The pool the happy hour was really nice very relaxed nice activities front desk was very helpful at all times"
The price is AU$158
includes taxes & fees
8 Sept - 9 Sept
Drury Inn & Suites Sikeston, MO

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
9.6 out of 10, Exceptional, (1002)
"Very nice hotel and nice staff "
The price is AU$155
includes taxes & fees
14 Sept - 15 Sept
Drury Plaza Hotel Cape Girardeau Conference Center

Super 8 by Wyndham Potosi

2.0 star property
7.0 out of 10, Good, (366)
"The room was very good for the price."
The price is AU$88
includes taxes & fees
8 Sept - 9 Sept
Super 8 by Wyndham Potosi

The Riverview

2.0 star property
9.4 out of 10, Exceptional, (409)
"From the moment we walked in we were impressed with the customer service, facility & cleanliness. We enjoyed every part of our one night stay! We would definitely stay here again "
The price is AU$182
includes taxes & fees
7 Sept - 8 Sept
The Riverview

Festus Inn

2.0 star property
5.8 out of 10, (35)
"This hotel was a very nice! I was expecting it to be nice but it was actually a lot nicer than I thought it was going to be!!! Will definitely stay here again in the future if I have the means/a reason too!"
The price is AU$157
includes taxes & fees
5 Sept - 6 Sept
Festus Inn

Echo Bluff State Park

2.5 star property
9.4 out of 10, Exceptional, (207)
"Beautiful location & very friendly staff!"
The price is AU$305
includes taxes & fees
7 Sept - 8 Sept
Echo Bluff State Park
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Southeast Missouri, MO

Showing deals for:12 Sept - 14 Sept
Save an average of 15% on thousands of hotels when you're signed in

Stay near top Southeast Missouri attractions

Elephant Rocks State Park
Elephant Rocks State Park

Elephant Rocks State Park

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

Rocky Falls
Rocky Falls

Rocky Falls

Commune with nature and explore the great outdoors at Rocky Falls during your travels in Winona. While you're in the area, wander around the natural setting.

Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from Sam A. Baker State Park to K Bridge Recreation Area.

Top Southeast Missouri Hotel Reviews

Explore a world of travel with Expedia

Explore a world of travel with Expedia