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Our top choices for Southeast Missouri hotels
1. Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
9.6 out of 10, Exceptional, (1,011 reviews)
"Breakfast was good,pool hot tub excellent "
Janica
The price is AU$181
includes taxes & fees
9 July - 10 July
2. Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1,013 reviews)
"Very clean, helpful staff"
Cathy
The price is AU$160
includes taxes & fees
5 July - 6 July
3. Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (915 reviews)
"Hotel Staff was very friendly!"
Alice
The price is AU$162
includes taxes & fees
21 June - 22 June
4. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
9.4 out of 10, Exceptional, (1,001 reviews)
"The room was very spacious and great water pressure. Staff very kind to us, the breakfast was great as well"
Theresa
The price is AU$182
includes taxes & fees
21 June - 22 June
5. Hampton Inn Poplar Bluff
Hampton Inn Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (871 reviews)
"Nice quiet overnight stay."
Tammy
The price is AU$148
includes taxes & fees
5 July - 6 July
6. Courtyard by Marriott Cape Girardeau Downtown
Courtyard by Marriott Cape Girardeau DowntownCape Girardeau
9.6 out of 10, Exceptional, (518 reviews)
"Great stay!!"
Taylor
The price is AU$201
includes taxes & fees
28 June - 29 June
7. Hampton Inn Sikeston
Hampton Inn SikestonSikeston
9.0 out of 10, Wonderful, (576 reviews)
"Very clean hotel with comfortable bedding. Front desk staff was very nice and accommodating as we were traveling with a small dog."
Connie
The price is AU$163
includes taxes & fees
12 July - 13 July
8. Drury Inn & Suites Poplar Bluff
Drury Inn & Suites Poplar BluffPoplar Bluff
9.2 out of 10, Wonderful, (1,011 reviews)
"Great place to stay. Clean, great staff and the food is good. Would stay again."
Stephanie
The price is AU$151
includes taxes & fees
21 June - 22 June
9. Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
9.4 out of 10, Exceptional, (84 reviews)
"Great stay, kind staff, very clean property."
Joni
The price is AU$177
includes taxes & fees
25 June - 26 June
10. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
9.0 out of 10, Wonderful, (781 reviews)
"Beautiful hotel at a very good price."
Sheldon
The price is AU$142
includes taxes & fees
14 June - 15 June
11. Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
9.6 out of 10, Exceptional, (1,017 reviews)
"The breakfast and nightly gathering makes this location a fantastic value and will be our choice of stops when heading south again!"
William
The price is AU$132
includes taxes & fees
12 July - 13 July
12. Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (1,012 reviews)
"I will definitely be staying here next time I visit SEMO."
Lee
The price is AU$154
includes taxes & fees
12 July - 13 July
13. The Riverview
The RiverviewCape Girardeau
9.4 out of 10, Exceptional, (596 reviews)
"Always a great place to stay in downtown Cape. Easy access to the local hangouts like Speck Pizza on Broadway."
John
The price is AU$193
includes taxes & fees
24 June - 25 June
14. Holiday Inn Express & Suites Sikeston Southwest by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHGSikeston
8.6 out of 10, Excellent, (467 reviews)
"Only stayed one night, no complaints"
Zachary
The price is AU$169
includes taxes & fees
12 July - 13 July
15. La Quinta Inn & Suites by Wyndham Festus - St. Louis South
La Quinta Inn & Suites by Wyndham Festus - St. Louis SouthFestus
8.0 out of 10, Very good, (1,001 reviews)
"Clean room, check in was easy. It was a good stopover for 1 night."
Nancy
The price is AU$136
includes taxes & fees
16 June - 17 June
16. Tru By Hilton Cape Girardeau
Tru By Hilton Cape GirardeauCape Girardeau
9.6 out of 10, Exceptional, (135 reviews)
"This is a clean, quiet, well designed hotel."
Kendra
The price is AU$144
includes taxes & fees
1 July - 2 July
17. Hampton Inn Cape Girardeau I 55 East
Hampton Inn Cape Girardeau I 55 EastCape Girardeau
9.6 out of 10, Exceptional, (822 reviews)
"A nice stay"
DAVID
The price is AU$169
includes taxes & fees
2 July - 3 July
18. Hampton Inn Farmington
Hampton Inn FarmingtonFarmington
8.8 out of 10, Excellent, (560 reviews)
"The room was spotless, staff and front desk were very friendly and helpful. Breakfast was good. I stay here once or twice a year and always happy with my stay"
Kathy
The price is AU$166
includes taxes & fees
28 June - 29 June
19. Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (197 reviews)
"The hotel was super clean, very friendly, the beds were very comfortable."
Candia
The price is AU$148
includes taxes & fees
2 July - 3 July
20. Motel 6 Poplar Bluff, MO
Motel 6 Poplar Bluff, MOPoplar Bluff
8.0 out of 10, Very good, (1,002 reviews)
"Clean room and convenient location."
Morgan
The price is AU$119
includes taxes & fees
15 June - 16 June
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Holiday Rentals in Southeast Missouri
Cabin
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
9.8 out of 10, Exceptional, (75 reviews)
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Learn more about Southeast Missouri
Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Clearwater Lake.
Photo by Bill Dillard
Open Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews
Baymont Inn and Suites by Wyndham Farmington, MO
10/10 Excellent
More cheap accommodation in Southeast Missouri
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
The price is AU$90 per night from 5 July to 6 July
AU$90
5 July - 6 July
includes taxes & fees
8/10 Very Good! (1,012 reviews)
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