Search Southeast Missouri hotels

Start date: Check-in selected.
End date: Check-out
    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
8 Sept - 9 Sept
Tomorrow
9 Sept - 10 Sept
This weekend
12 Sept - 14 Sept
Next weekend
19 Sept - 21 Sept

Filter by

Guest rating
Guest rating
Star rating

Top hotels and accommodation in Southeast Missouri

Our top choices for Southeast Missouri hotels

Postcard Cabins St. Francois
Exterior

Postcard Cabins St. Francois

2.0 star property
10.0 out of 10, Exceptional, (30)
"Sweet cabin"
The price is AU$203
includes taxes & fees
9 Sept - 10 Sept
Postcard Cabins St. Francois
Super 8 by Wyndham Farmington
Exterior

Super 8 by Wyndham Farmington

2.0 star property
8.0 out of 10, Very good, (585)
"Very friendly staff who make sure guests are taken care of! Clean, great location, and safe place to stay. "
The price is AU$93
includes taxes & fees
14 Sept - 15 Sept
Super 8 by Wyndham Farmington
The Farmstead Hotel
Front of property

The Farmstead Hotel

2.5 star property
8.8 out of 10, Excellent, (406)
"Great place. "
The price is AU$198
includes taxes & fees
14 Sept - 15 Sept
The Farmstead Hotel
Holiday Inn Express & Suites Perryville by IHG
Exterior

Holiday Inn Express & Suites Perryville by IHG

2.5 star property
9.4 out of 10, Exceptional, (503)
"Have stayed here the past 3 years during the Laid Back on I-55 Truck Show! Great place to stay! The breakfast is fantastic!! The staff does not disappoint!! "
The price is AU$166
includes taxes & fees
14 Sept - 15 Sept
Holiday Inn Express & Suites Perryville by IHG
Pear Tree Inn Cape Girardeau West
Lobby

Pear Tree Inn Cape Girardeau West

2.5 star property
9.0 out of 10, Wonderful, (1003)
"Great place to stay. Safe and quiet indoors and close to get in the road again tomorrow. Staff was friendly! "
The price is AU$120
includes taxes & fees
14 Sept - 15 Sept
Pear Tree Inn Cape Girardeau West
Drury Inn & Suites Jackson MO
Lobby

Drury Inn & Suites Jackson MO

3.0 star property
9.6 out of 10, Exceptional, (1002)
"Employees were extremely helpful and happy to help!"
The price is AU$145
includes taxes & fees
13 Sept - 14 Sept
Drury Inn & Suites Jackson MO
Baymont Inn and Suites by Wyndham Farmington, MO
Business centre

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 star property
8.0 out of 10, Very good, (1003)
"Great location"
The price is AU$90
includes taxes & fees
14 Sept - 15 Sept
Baymont Inn and Suites by Wyndham Farmington, MO
Drury Inn & Suites Cape Girardeau
Business centre

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (988)
"The staff was beyond friendly, the free breakfast did not disappointed, and we were just genuinely happy with our stay."
The price is AU$155
includes taxes & fees
13 Sept - 14 Sept
Drury Inn & Suites Cape Girardeau
Super 8 by Wyndham Perryville
Exterior

Super 8 by Wyndham Perryville

2.0 star property
8.4 out of 10, Very good, (907)
" Love the stay and staff was great "
The price is AU$126
includes taxes & fees
14 Sept - 15 Sept
Super 8 by Wyndham Perryville
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Property amenity

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3.0 star property
8.8 out of 10, Excellent, (611)
"Excellent place to stay. Breakfast was good and staff was friendly. "
The price is AU$139
includes taxes & fees
10 Sept - 11 Sept
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Free buffet breakfast

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

2.5 star property
9.4 out of 10, Exceptional, (678)
"Great place to stay!"
The price is AU$221
includes taxes & fees
14 Sept - 15 Sept
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Drury Inn & Suites Hayti Caruthersville
Lobby

Drury Inn & Suites Hayti Caruthersville

3.0 star property
9.4 out of 10, Exceptional, (1001)
"Great place"
The price is AU$163
includes taxes & fees
21 Sept - 22 Sept
Drury Inn & Suites Hayti Caruthersville
Comfort Inn Festus - St Louis South
Lobby sitting area

Comfort Inn Festus - St Louis South

2.5 star property
8.0 out of 10, Very good, (873)
"The room was clean and the hallways were clean. The breakfast was good and the room was affordable. Just what we were looking for!"
The price is AU$138
includes taxes & fees
14 Sept - 15 Sept
Comfort Inn Festus - St Louis South
Drury Plaza Hotel Cape Girardeau Conference Center
Lobby

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
9.6 out of 10, Exceptional, (1006)
"Very nice hotel and nice staff "
The price is AU$155
includes taxes & fees
14 Sept - 15 Sept
Drury Plaza Hotel Cape Girardeau Conference Center
Pear Tree Inn Cape Girardeau Near the Medical Center
Lobby

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1002)
"Excellent place to stay "
The price is AU$120
includes taxes & fees
14 Sept - 15 Sept
Pear Tree Inn Cape Girardeau Near the Medical Center
Drury Inn & Suites Sikeston, MO
Property amenity

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1003)
"The pool the happy hour was really nice very relaxed nice activities front desk was very helpful at all times"
The price is AU$158
includes taxes & fees
14 Sept - 15 Sept
Drury Inn & Suites Sikeston, MO
The Riverview
Lobby sitting area

The Riverview

2.0 star property
9.4 out of 10, Exceptional, (411)
"From the moment we walked in we were impressed with the customer service, facility & cleanliness. We enjoyed every part of our one night stay! We would definitely stay here again "
The price is AU$181
includes taxes & fees
14 Sept - 15 Sept
The Riverview
Festus Inn
Banquet hall

Festus Inn

2.0 star property
6.0 out of 10, (37)
"very friendly staff "
The price is AU$156
includes taxes & fees
9 Sept - 10 Sept
Festus Inn
Super 8 by Wyndham Potosi
Standard Room, 1 King Bed

Super 8 by Wyndham Potosi

2.0 star property
7.0 out of 10, Good, (366)
"The room was very good for the price."
The price is AU$88
includes taxes & fees
14 Sept - 15 Sept
Super 8 by Wyndham Potosi
Echo Bluff State Park
Front of property

Echo Bluff State Park

2.5 star property
9.4 out of 10, Exceptional, (207)
"Beautiful location & very friendly staff!"
The price is AU$305
includes taxes & fees
9 Sept - 10 Sept
Echo Bluff State Park
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Southeast Missouri, MO

Showing deals for:19 Sept - 21 Sept

Image gallery for Tiny Houses of French Village

House | Living area

Tiny Houses of French Village

2.5 star property
French Village
10/10Exceptional (3 reviews)
9% off
Price is AU$887
for 2 nights, 1 home
AU$443 per night
includes taxes & fees
Tiny Houses of French Village
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from Sam A. Baker State Park to K Bridge Recreation Area.

See all hotels in Southeast Missouri

Top Southeast Missouri Hotel Reviews

More cheap accommodation in Southeast Missouri

More cheap accommodation in Southeast Missouri

The Riverview

The Riverview

777 Main St, Cape Girardeau, MO
The price is AU$181 per night from 14 Sept to 15 Sept
AU$181
14 Sept - 15 Sept
includes taxes & fees

Explore a world of travel with Expedia

Explore a world of travel with Expedia