Photo by Bill Dillard

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Top hotels and accommodation in Southeast Missouri

The Farmstead Hotel

2.5 star property
Caruthersville
8.8 out of 10, Excellent, (460)
"Clean rooms and really comfortable beds!"
United States
Andrea
The price is AU$136
includes taxes & fees
8 Jan - 9 Jan 2026
The Farmstead Hotel

Holiday Inn Express & Suites Perryville by IHG

2.5 star property
Perryville
9.2 out of 10, Wonderful, (537)
"Clean room and pleasant staff"
United States
David
The price is AU$150
includes taxes & fees
14 Dec - 15 Dec
Holiday Inn Express & Suites Perryville by IHG

Drury Inn & Suites Jackson MO

3.0 star property
Jackson
9.6 out of 10, Exceptional, (1005)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is AU$132
includes taxes & fees
9 Dec - 10 Dec
Drury Inn & Suites Jackson MO

Baymont by Wyndham Festus

3.0 star property
Festus
6.8 out of 10, (918)
"Room was clean and comfortable for an overnight stay"
United States
Jack
The price is AU$139
includes taxes & fees
14 Dec - 15 Dec
Baymont by Wyndham Festus

Super 8 by Wyndham Farmington

2.0 star property
Farmington
8.0 out of 10, Very good, (610)
"Clean, friendly staff, quiet"
United States
Stacy
The price is AU$95
includes taxes & fees
15 Dec - 16 Dec
Super 8 by Wyndham Farmington

Pear Tree Inn Cape Girardeau West

2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1003)
"Great stay"
United States
Heather
The price is AU$119
includes taxes & fees
14 Dec - 15 Dec
Pear Tree Inn Cape Girardeau West

Super 8 by Wyndham Perryville

2.0 star property
Perryville
8.4 out of 10, Very good, (937)
"The room was spotless, and the staff was extremely patient. Each one was very helpful. It was easy to get a good night's sleep - the building was very quiet."
United States
Cynthia
The price is AU$107
includes taxes & fees
25 Dec - 26 Dec
Super 8 by Wyndham Perryville

Drury Inn & Suites Hayti Caruthersville

3.0 star property
Hayti
9.4 out of 10, Exceptional, (1001)
"Staff is very friendly. Breakfast was good. "
United States
Samantha
The price is AU$161
includes taxes & fees
13 Dec - 14 Dec
Drury Inn & Suites Hayti Caruthersville

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

2.5 star property
Festus
9.4 out of 10, Exceptional, (698)
"Great place to stay!"
United States
Tracy
The price is AU$203
includes taxes & fees
14 Dec - 15 Dec
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Holiday Inn Poplar Bluff by IHG

3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (696)
"Amazing place"
United States
Mladen
The price is AU$187
includes taxes & fees
14 Dec - 15 Dec
Holiday Inn Poplar Bluff by IHG

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1004)
"Nice place for a stay at a reasonable price."
United States
Arthur
The price is AU$119
includes taxes & fees
14 Dec - 15 Dec
Pear Tree Inn Cape Girardeau Near the Medical Center

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1001)
"Great place and staff, very accommodating!"
United States
Megan
The price is AU$153
includes taxes & fees
14 Dec - 15 Dec
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Inn & Suites Cape Girardeau

3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1002)
"I do love this hotel chain. Another great visit!"
United States
Mark
The price is AU$153
includes taxes & fees
14 Dec - 15 Dec
Drury Inn & Suites Cape Girardeau

Hampton Inn Sikeston

2.5 star property
Sikeston
9.0 out of 10, Wonderful, (440)
"Room was clean and cozy, the check in-out staff were really nice and asked about our stay as well and the breakfast was a nice variety."
United States
Doncheial
The price is AU$162
includes taxes & fees
14 Dec - 15 Dec
Hampton Inn Sikeston

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3.0 star property
Jackson
8.8 out of 10, Excellent, (661)
"Great place "
United States
GUY
The price is AU$127
includes taxes & fees
4 Jan - 5 Jan 2026
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 star property
Farmington
8.0 out of 10, Very good, (1007)
"Room was clean , staff was friendly !"
United States
Sally
The price is AU$93
includes taxes & fees
14 Dec - 15 Dec
Baymont Inn and Suites by Wyndham Farmington, MO

Super 8 by Wyndham Potosi

2.0 star property
Potosi
7.0 out of 10, Good, (378)
"The room was very good for the price."
United States
Benjamin
The price is AU$91
includes taxes & fees
9 Dec - 10 Dec
Super 8 by Wyndham Potosi

The Riverview

4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (465)
"Place was nice and safe"
United States
ryan
The price is AU$149
includes taxes & fees
15 Dec - 16 Dec
The Riverview

Echo Bluff State Park

2.5 star property
Eminence
9.6 out of 10, Exceptional, (216)
"Beautiful location…excellent service and facilities / grounds were clean and well kept."
United States
William
The price is AU$243
includes taxes & fees
8 Jan - 9 Jan 2026
Echo Bluff State Park
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Southeast Missouri, MO

Showing deals for:19 Dec - 21 Dec
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Stay near popular Central United States attractions

Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from Sam A. Baker State Park to Walnut Hollow Lake.

Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg:

Moark Regional Railroad Museum
HOURS: Saturdays 1 p.m. - 4 p.m.

It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history.

This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! 

#MTTS2014 #minitakesthestates #go11
#train
Photo by Bill Dillard
Open Photo by Bill Dillard

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