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Our top choices for Southeast Missouri hotels
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1,003 reviews)
"Great place "
Kelly
The price is AU$165
includes taxes & fees
29 Jan - 30 Jan
Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
9.6 out of 10, Exceptional, (1,006 reviews)
"Suited our purpose for overnight on a road trip "
Angela
The price is AU$124
includes taxes & fees
29 Jan - 30 Jan
The Farmstead Hotel
The Farmstead HotelCaruthersville
8.8 out of 10, Excellent, (476 reviews)
"Clean room, very nice staff"
Mack
The price is AU$126
includes taxes & fees
24 Jan - 25 Jan
Echo Bluff State Park
Echo Bluff State ParkEminence
9.4 out of 10, Exceptional, (220 reviews)
"This entire trip was inspired by Tina, a staff member. I met Tina passing through the area and she provided me with a lot of information which gave me the idea to plan a weekend trip with my wife. The lodge room we had was clean and comfortable, My wife and I had a wonderful time exploring most of the areas Tina mentioned. Thank you Tina for a wonderful inspiration for a get away. "
Jared
The price is AU$238
includes taxes & fees
1 Feb - 2 Feb
Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
9.2 out of 10, Wonderful, (52 reviews)
"THE ROOM WAS SPOTLESS, CLEAN LOBBY, WARM AND LOT OF VARITY BREAKFAST, STAFF IS SO NICE."
AHMAD
The price is AU$169
includes taxes & fees
29 Jan - 30 Jan
The Riverview
The RiverviewCape Girardeau
9.4 out of 10, Exceptional, (493 reviews)
"The room was clean and I was able to check in a bit early."
Sara
The price is AU$157
includes taxes & fees
26 Jan - 27 Jan
Tru By Hilton Cape Girardeau
Tru By Hilton Cape GirardeauCape Girardeau
9.6 out of 10, Exceptional, (107 reviews)
"It was a nice stay"
Douglas
The price is AU$149
includes taxes & fees
29 Jan - 30 Jan
Holiday Inn Express & Suites Perryville by IHG
Holiday Inn Express & Suites Perryville by IHGPerryville
9.2 out of 10, Wonderful, (554 reviews)
"lean, updated rooms, friendly staff and great breakfast."
Linda
The price is AU$152
includes taxes & fees
29 Jan - 30 Jan
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
9.0 out of 10, Wonderful, (690 reviews)
"Conveniently located, clean, friendly staff."
Philip
The price is AU$126
includes taxes & fees
26 Jan - 27 Jan
Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (868 reviews)
"The size of the room. The staff were great. The room was very clean. Will definitely stay there again."
Brenda
The price is AU$176
includes taxes & fees
31 Jan - 1 Feb
Holiday Inn Poplar Bluff by IHG
Holiday Inn Poplar Bluff by IHGPoplar Bluff
8.8 out of 10, Excellent, (715 reviews)
"Amazing place"
Mladen
The price is AU$188
includes taxes & fees
21 Feb - 22 Feb
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
9.4 out of 10, Exceptional, (1,002 reviews)
"As always it was a perfect visit"
John
The price is AU$153
includes taxes & fees
27 Jan - 28 Jan
Courtyard by Marriott Cape Girardeau Downtown
Courtyard by Marriott Cape Girardeau DowntownCape Girardeau
9.6 out of 10, Exceptional, (483 reviews)
"Very nice hotel!"
Angie
The price is AU$207
includes taxes & fees
22 Feb - 23 Feb
Hampton Inn Sikeston
Hampton Inn SikestonSikeston
9.0 out of 10, Wonderful, (465 reviews)
"Very clean and super friendly staff!"
Katherine
The price is AU$165
includes taxes & fees
22 Feb - 23 Feb
Best Western Plus Sikeston
Best Western Plus SikestonSikeston
8.4 out of 10, Very good, (1,004 reviews)
"Great stay, everything was clean and comfortable. "
Charles
The price is AU$136
includes taxes & fees
22 Feb - 23 Feb
Honeysuckle Inn - Mountain View
Honeysuckle Inn - Mountain ViewMountain View
8.6 out of 10, Excellent, (337 reviews)
"Staff was very friendly."
Joyce
The price is AU$143
includes taxes & fees
25 Jan - 26 Jan
Fort Davidson Hotel
Fort Davidson HotelIronton
9.2 out of 10, Wonderful, (175 reviews)
"Fantastic local hotel that’s right next to a state historic site. A must stay if in the area"
Graham
The price is AU$188
includes taxes & fees
24 Jan - 25 Jan
Holiday Inn Express & Suites Sikeston Southwest by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHGSikeston
8.6 out of 10, Excellent, (447 reviews)
"Stay was excellent "
Kourtney
The price is AU$156
includes taxes & fees
8 Feb - 9 Feb
Motel 6 Poplar Bluff, MO
Motel 6 Poplar Bluff, MOPoplar Bluff
8.0 out of 10, Very good, (1,001 reviews)
"Very clean and staff was very friendly!"
Sherry
The price is AU$88
includes taxes & fees
30 Jan - 31 Jan
Drury Inn & Suites Poplar Bluff
Drury Inn & Suites Poplar BluffPoplar Bluff
9.2 out of 10, Wonderful, (985 reviews)
"Great location and room "
Curtis
The price is AU$168
includes taxes & fees
2 Feb - 3 Feb
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Holiday Rentals in Southeast Missouri
Cabin
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
9.8 out of 10, Exceptional, (48 reviews)
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Stay near popular Central United States attractions
Learn more about Southeast Missouri
Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.
Photo by Bill Dillard
Open Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews
Recent Reviews in Southeast Missouri
Candlewood Suites Cape Girardeau by IHG
10/10 Excellent
More cheap accommodation in Southeast Missouri
Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
The price is AU$88 per night from 30 Jan to 31 Jan
AU$88
30 Jan - 31 Jan
includes taxes & fees
7.8/10 Good! (1,001 reviews)
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