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Check prices for these dates
Tonight
12 Sept - 13 SeptTomorrow
13 Sept - 14 SeptNext weekend
18 Sept - 20 SeptIn two weeks
25 Sept - 27 SeptOur top choices for Southeast Missouri hotels
1. Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
William
AU$121
includes taxes & fees
20 Sept - 21 Sept
2. Madison Inn Lodge
Madison Inn LodgeFredericktown
Bawan
AU$133
includes taxes & fees
14 Sept - 15 Sept
3. Fort Davidson Hotel
Fort Davidson HotelIronton
richard
AU$190
includes taxes & fees
13 Sept - 14 Sept
4. Shepherd Mountain Inn
Shepherd Mountain InnIronton
Katie
AU$188
includes taxes & fees
16 Sept - 17 Sept
5. Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
Sandra
AU$157
includes taxes & fees
17 Sept - 18 Sept
6. Hampton Inn Poplar Bluff
Hampton Inn Poplar BluffPoplar Bluff
Theresa
AU$146
includes taxes & fees
4 Oct - 5 Oct
7. Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
Allen
AU$160
includes taxes & fees
20 Sept - 21 Sept
8. EC Reed's Mercantile and Hotel
EC Reed's Mercantile and HotelMarble Hill
JANEEN
AU$116
includes taxes & fees
20 Sept - 21 Sept
9. Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
Arsenia
AU$159
includes taxes & fees
4 Oct - 5 Oct
10. Holiday Inn Express & Suites Perryville by IHG
Holiday Inn Express & Suites Perryville by IHGPerryville
David
AU$155
includes taxes & fees
4 Oct - 5 Oct
11. Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
Scott Andrew
AU$164
includes taxes & fees
17 Sept - 18 Sept
12. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
Andrew
AU$140
includes taxes & fees
13 Sept - 14 Sept
13. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
Ronrecus
AU$210
includes taxes & fees
16 Sept - 17 Sept
14. The Riverview
The RiverviewCape Girardeau
Alyssa
AU$167
includes taxes & fees
16 Sept - 17 Sept
15. Echo Bluff State Park
Echo Bluff State ParkEminence
Penny
AU$307
includes taxes & fees
13 Sept - 14 Sept
16. Holiday Inn Poplar Bluff by IHG
Holiday Inn Poplar Bluff by IHGPoplar Bluff
Stephanie
AU$134
includes taxes & fees
11 Oct - 12 Oct
17. Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
Carlos
AU$159
includes taxes & fees
1 Oct - 2 Oct
18. Crown Pointe Lodge, BW Signature Collection
Crown Pointe Lodge, BW Signature CollectionFarmington
Susan
AU$166
includes taxes & fees
28 Sept - 29 Sept
19. Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau WestCape Girardeau
Raidas
AU$113
includes taxes & fees
4 Oct - 5 Oct
20. Holiday Inn Express & Suites Sikeston Southwest by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHGSikeston
michael
AU$155
includes taxes & fees
11 Oct - 12 Oct
Holiday Rentals in Southeast Missouri
Cabin
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
"I really enjoyed my time at the stay !"
Aparthotel
The Atrium - A Boutique Hotel
The Atrium - A Boutique HotelPerryville
"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."
Cottage
Walk to Current River: Ozarks Adventure Home!
Walk to Current River: Ozarks Adventure Home!Van Buren
"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."
Holiday Home
Tiny Houses of French Village
Tiny Houses of French VillageFrench Village
"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "
Cottage
'turtle Rock' - Ironton Cabin w/ Furnished Patio!
'turtle Rock' - Ironton Cabin w/ Furnished Patio!Ironton
"Stroller, pack n play and high chair. This was amazing "
Cottage
Cozy Belgrade Cottage w/ Wood-burning Stove!
Cozy Belgrade Cottage w/ Wood-burning Stove!Belgrade
Cottage
Cottage w/ Yard, Walk to Historic Attractions
Cottage w/ Yard, Walk to Historic AttractionsSte Genevieve
"The little blue cottage was very comfortable, clean and close to everything downtown. We parked the car and walked everywhere. It was on a quiet street. The bed was comfy, clean kitchen. We liked the little back yard, for relaxing. "
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Stay near popular Southeast Missouri attractions
Photo by Pat Long
Elephant Rocks State Park
9.6/10 (98 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
Southeast Missouri State University
8.8/10 (248 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.
Big Spring
9.8/10 (19 reviews)
Enjoy an outing to Big Spring during your stay in Van Buren. Wander the forests and riverfront while you're in the area.
Current River State Park
9.2/10 (20 reviews)
Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.
Century Casino & Hotel Cape Girardeau
8.4/10 (176 reviews)
Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your time in Cape Girardeau? While in this family-friendly area, you can savour the top-notch restaurants.
Century Casino Caruthersville
7.0/10 (57 reviews)
Why not try your luck with a visit to Century Casino Caruthersville during your visit to Caruthersville? While in this family-friendly area, you can enjoy the restaurants.
Learn more about Southeast Missouri
Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.
See all hotels in Southeast Missouri
Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews
Recent Reviews in Southeast Missouri
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
10/10 Excellent
"We love the room and location"
Drury Inn & Suites Hayti Caruthersville
8/10 Good
"Staff was very professional and accommodating. Cons: room had lingering smell of smoking."
Holiday Inn Express & Suites Perryville by IHG
8/10 Good
"Clean and nice. Late check in but staff was very helpful and quick. Bedding was nice, mattress was more firm than I like but not uncomfortable."
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
10/10 Excellent
"Perfect trip!!! I can’t wait to go back when it gets colder outside :)"
Drury Inn & Suites Sikeston, MO
10/10 Excellent
"All good, staff friendly and helpful! Breakfast was great and kick back dinner was good!"
The Riverview
10/10 Excellent
"Very clean They need a fitness center !"
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
10/10 Excellent
"."
Motel 6 Poplar Bluff, MO
10/10 Excellent
"Nice"
Best Western Plus Sikeston I-55
8/10 Good
"Great location, nice, clean and well maintained, Hotel employees were very helpful great customer service,"
More cheap accommodation in Southeast Missouri
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
AU$86
20 Sept - 21 Sept
includes taxes & fees
8/10 Very good! (1,006 reviews)
Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr Sikeston MO
AU$105
17 Sept - 18 Sept
includes taxes & fees
Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy Cape Girardeau MO
AU$113
4 Oct - 5 Oct
includes taxes & fees
Comfort Inn Festus - St Louis South
1303 Veterans Blvd Festus MO
AU$116
11 Oct - 12 Oct
includes taxes & fees
The Farmstead Hotel
778 E 3rd St Caruthersville MO
AU$151
13 Sept - 14 Sept
includes taxes & fees
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
3253 William Street Cape Girardeau MO
AU$161
20 Sept - 21 Sept
includes taxes & fees
9.4/10 Exceptional! (1,001 reviews)
